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KMID : 0861020070220020169
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Korea Journal of Herbology
2007 Volume.22 No. 2 p.169 ~ p.174
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Effects of Sayeoksanhap-Pyeongweisan-Gamiban(SPG) on hematological changes in animals damaged by CCl4
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Kim Hyung-Woo
Kim Seong-Wook
Cho Soo-Jin
Kim Bu-Yeo
Yun Yeo-Choong
Cho Su-In
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Abstract
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Objectives : This study was designed to investigate protective effects of Sayeoksanhap-Pyeongweisan-Gamiban(SPG) on hematological changes in rats damaged by CCl4
Methods : We investigated the effects of SPG on hematological changes in terms of AST/ALT levels, Total cholesterol, HDL-cholesterol and triglyceride in serum and lipid peroxidation in rat liver.
Results : Administration of SPG decreased AST level in serum effectively. In addition, lipid peroxidation in liver tissue, which was elevated by injection of CCl4, was decreased by administration of SPG. In contrast, ALT level, Total cholesterol, HDL-cholesterol and triglyceride in serum were not affected by administration of SPG.
Conclusion : These results suggest that oral administration of SPG was useful to protect liver against CCl4 by its antioxidant action in liver tissues.
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KEYWORD
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sayeoksan, Pyeongweisan, CCl4, Lipid peroxidation
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